Little Known Facts About ceesdekker.
Little Known Facts About ceesdekker.
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‘Of course, that is about appropriate. I search for a physical idea of biological programs inside of a bottom-up way. I feel you could potentially distinguish three traces of investigate in my group at this time. The very first problems chromosome composition: How can you get yourself a metre-extensive DNA polymer folded and organised in such a microscopic mobile? We've designed visualisation procedures that allow for us to review how, such as, SMC proteins loop DNA (video clip on Youtube) so that you can build up chromosomes.
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2007, initially real-time detection of strand exchange in homologous recombination by RecA; discovery of the minimal persistence duration of finishes of microtubules; and settled the system of biosensing with carbon nanotubes
2015, discovery that condensin is usually a hugely flexible protein composition; and initially detection of DNA knots employing nanopores
Immediate immobilization of indigenous yeast iso-one cytochrome c on bare gold: quick electron relay to redox enzymes and zeptomole protein-film voltammetry
What distinguishes biology from chemistry is the fact these components with each other make up a residing process. The trick of stated daily life, I feel, lies in the interactions, the interplay of People molecules. The massive dilemma regarding the origin of daily life remains unanswered. How did we at any time evolve from very simple molecules into the really advanced units we see these days? We don't know. I would like to work on these kinds of huge, open inquiries.’
Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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Quite amazing, but that wasn’t genuinely the place my curiosity lay. I desired to pioneer and I experienced the sensation that was not feasible, because the most interesting essential insights experienced presently been uncovered. But my discipline had formulated lots of remarkable new tools to evaluate person molecules. I decided which i wished to apply this to biology, to have a look at it from the physical point of view.’
Screening pseudotopological and nontopological types for SMC-pushed DNA loop extrusion in opposition to roadblock-traversal experiments
Character Physics thanks the nameless reviewers for their contribution into the peer assessment of this get the job done.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style and design in 2005. (nl)